Laboratory of Lymphocyte Signaling and Oncoproteome

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Dual STAT3/STAT5 inhibition as a novel treatment strategy in T-prolymphocytic leukemia

Dechow, Annika Timonen, Sanna Ianevski, Aleksandr Jiang, Qu Neubauer, Heidi A. Becker, Kerstin Schrader, Alexandra Hallek, Michael Wahnschaffe, Linus Peng, Yayi Jungherz, Dennis Schönefeldt, Susann de Araujo, Elvin Herling, MarcoLeukemia, 2025

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Multiomic profiling of T cell lymphoma after therapy with anti-BCMA CAR T cells and GPRC5D-directed bispecific antibody

Braun, Till Rade, Michael Merz, Maximilian Klepzig, Hanna Große, Florian Fandrei, David Pham, Nhu-Nguyen Kreuz, Markus Kuhn, Christina Katharina Kuschel, Florian Löffler, Dennis Meinel, Jörn Heger, Eva Schweinsberg, Viola Pflug, Natali Platzbecker, Uwe Hallek, Michael Holtick, Udo Köhl, Ulrike Scheid, Christof Reiche, Kristin Herling, Marco Richardson, TimNature Medicine, 2025

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The Modes of Dysregulation of the Proto-Oncogene T-Cell Leukemia/Lymphoma 1A

Stachelscheid, Johanna Jiang, Qu Herling, MarcoCancers (Basel), 2021

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Consensus criteria for diagnosis, staging, and treatment response assessment of T-cell prolymphocytic leukemia (T-PLL)

Staber, Philipp B.Herling, MarcoBellido, MarJacobsen, Eric D.Davids, Matthew S.Kadia, Tapan MahendraShustov, AndreiTournilhac, OlivierBachy, EmmanuelZaja, FrancescoPorkka, KimmoHoermann, GregorSimonitsch, IngridHaferlach, ClaudiaKubicek, StefanMayerhoefer, MariusHopfinger, GeorgJaeger, UlrichDearden, ClaireBlood, 2019

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Actionable perturbations of damage responses by TCL1/ATM and epigenetic lesions form the basis of T-PLL

Schrader, A Crispatzu, G Oberbeck, S Mayer, P Pützer, S von Jan, J Vasyutina, E Warner, K Weit, N Pflug, N Braun, T Andersson, EI Yadav, B Riabinska, A Maurer, B Ventura Ferreira, MS Beier, F Altmüller, J Lanasa, M Herling, CD Haferlach, T Stilgenbauer, S Hopfinger, G Peifer, M Brümmendorf, TH Nürnberg, P Elenitoba-Johnson, KSJ Zha, S Hallek, M Moriggl, R Reinhardt, HC Stern, MH Mustjoki, S Newrzela, S Frommolt, P Herling, MNature Communications, 2018

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Targeting transcription-coupled nucleotide excision repair overcomes resistance in chronic lymphocytic leukemia

Lohmann, G Vasyutina, E Bloehdorn, J Reinart, N Schneider, J Babu, V Knittel, G Crispatzu, G Mayer, P Prinz, C‎ Biersack, B Efremov, D Chessa, L Herling, CD Stilgenbauer, S Hallek, M Schobert, R Reinhardt, HC Schumacher, B‎ Herling, MLeukemia, 2017

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Re-activation of mitochondrial apoptosis inhibits T cell lymphoma survival and treatment resistance

Spinner, S Crispatzu, G Yi JH Munkhbaatar, E Mayer, P Höckendorf, U Müller, N Li, Z Schader, T Bendz, H Hartmann, S Yabal, M Pechloff, K Heikenwalder, M Kelly, GL Strasser, A Peschel, C Hansmann, ML Ruland, J Keller, U Newrzela, SHerling, MJost, PJLeukemia, 2016

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The regulatory interaction of EVI1 with the TCL1A oncogene impacts cell survival and clinical outcome in CLL

Vasyutina, E Boucas, JM Bloehdorn, J Aszyk, C Crispatzu, G Stiefelhagen, M Breuer, A Mayer, P Lengerke, C Döhner, H Beutner, D Rosenwald, A Stilgenbauer, S Hallek, M Benner, A Herling, MLeukemia, 2015

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CD44 regulates the apoptotic response and promotes disease development in chronic lymphocytic leukemia

Fedorchenko, O Stiefelhagen, M Peer Zada, AA Barthel, R Mayer, P Eckei, L Breuer, A Crispatzu, G Rosen, N Landwehr, T Lilienthal, N Möllmann, M Montesinos-Rongen, M Heukamp, L Dürig, J Hallek, MFingerle-Rowson, GHerling, MBlood, 2013

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High TCL1 levels are a marker of B-cell receptor pathway responsiveness and therapy resistance in chronic lymphocytic leukemia

Herling, M Patel, KA Weit, N Lilienthal, N Hallek, M Keating, MJ Jones, DBlood, 2009

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High TCL1 expression and intact T-cell receptor signaling define a hyperproliferative subset of T-cell prolymphocytic leukemia

Herling, M Patel, KA Teitell, MA Konopleva, M Ravandi, F Kobayashi, R Jones, DBlood, 2008

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TCL1 shows a regulated expression pattern in chronic lymphocytic leukemia that correlates with molecular subtypes and proliferative state

Herling, M Patel, KA Khalili, J Schlette, E Kobayashi, R Medeiros, LJ Jones, DLeukemia, 2006

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A systematic approach to diagnosis of mature T-cell leukemias reveals heterogeneity among WHO categories

Herling, M Khoury, JD Washington, LT Duvic, M Keating, MJ Jones, DBlood, 2004

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TCL1 expression in plasmacytoid dendritic cells (DC2) and the related CD4+CD56+ blastic tumors of skin

Herling, M Teitell, MA Shen, RR Medeiros, LJ Jones, DBlood, 2003

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