Laboratory of Lymphocyte Signaling and Oncoproteome

New article accepted for publication

Our latest article “Non-canonical effector functions of the T-memory-like T-PLL cell are shaped by cooperative TCL1A and TCR signaling” by Sebastian Oberbeck, Alexandra Schrader, Kathrin Warner et al. has been accepted for publication in Blood.

In this study, we report two major findings:

  • T-PLL cells resemble activated T-lymphocytes with augmented memory-type effector functions including a marked anergy to apoptotic triggers
  • specific co-opting loss of inhibitory receptors and the overexpressed signal enhancer TCL1A lower thresholds towards permissive TCR input

We will add a link to the article as soon as the publication process has been completed.

New article accepted for publication
Postet on August 30, 2020

More news

New article accepted for publication

New article accepted for publication

August 30, 2020

Our work on T-PLL cells resembling the phenotype of activated memory-type effector T-cells has been accepted in Blood

Alkylating deacetylase inhibitor tinostamustine in T-PLL

March 11, 2020

New letter evaluating the effects of EDO-S101/tinostamustine published in Leukemia.